Document Detail


Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study.
MedLine Citation:
PMID:  5387729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxemia was induced in 13 of 20 pregnant ewes by the stress of a change in environment and food deprivation late in pregnancy. Of the toxemic ewes, eight developed prominent neurological findings with convulsions, motor weakness, and blindness, whereas five ewes developed azotemia without neurological signs. Proteinuria and azotemia occurred in all but one of the toxemic animals. Seven animals did not develop clinical or laboratory evidence of toxemia. Hypertension did not occur with the onset of toxemia but all toxemic animals showed glomerular changes by light and electron microscopy. These abnormalities, which were similar to those seen in human preeclampsia, included endothelial cell swelling, focal reduplication of the basement membrane, and fusion of the epithelial cell foot processes. The toxemia could not be attributed to changes in hematocrit, plasma glucose, Na, Cl, CO(2), K, Ca, fibrinogen, arterial pH, lactate, or pyruvate concentrations. Cardiac output fell only in ewes with prominent neurological signs. Plasma renin rose strikingly in animals developing toxemia, without change in substrate concentration. In contrast to human and other species, sheep uterus and amniotic fluid contained no detectable quantities of renin. Thus in response to stress the pregnant ewe develops a toxemia which in the absence of hypertension has clinical and pathological similarities to human preeclampsia.
Authors:
T F Ferris; P B Herdson; M S Dunnill; M R Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  48     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1969 Sep 
Date Detail:
Created Date:  1969-11-26     Completed Date:  1969-11-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1643-55     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / pathology
Animals
Blood Pressure
Brain / pathology
Cardiac Output
Female
Kidney Glomerulus / pathology
Liver / pathology
Microscopy, Electron
Neurologic Manifestations
Peripheral Nerves / pathology
Pre-Eclampsia / blood,  pathology*,  physiopathology*
Pregnancy
Sheep
Uterus / pathology
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