Document Detail

Towards a systems biology approach of-G protein-coupled receptor signalling: challenges and expectations.
MedLine Citation:
PMID:  19909918     Owner:  NLM     Status:  MEDLINE    
G protein-coupled receptors (GPCRs) control all the main physiological functions and are targeted by more than 50% of therapeutics. Our perception of GPCRs signalling has grown increasingly complex since it is now accepted that they activate large signalling networks which are integrating the information fluxes into appropriate biological responses. These concepts lead the way to the development of pathway-selective agonists (or antagonists) with fewer side effects. Systems biology approaches focused on GPCR-mediated signalling would help dealing with the huge complexity of these mechanisms therefore speeding-up the discovery of new drug classes. In this review, we present the various technical and conceptual possibilities allowing a systems approach of GPCR-mediated signalling. The main remaining limitations are also discussed.
Domitille Heitzler; Pascale Cr?pieux; Anne Poupon; Fr?d?rique Cl?ment; Fran?ois Fages; Eric Reiter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-14
Journal Detail:
Title:  Comptes rendus biologies     Volume:  332     ISSN:  1768-3238     ISO Abbreviation:  C. R. Biol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  947-57     Citation Subset:  IM    
BIOS group, INRA, UMR85, Unit? physiologie de la reproduction et des comportements, 37380 Nouzilly, France.
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MeSH Terms
Computational Biology
Computer Simulation
Drug Discovery
Fluorescence Resonance Energy Transfer
Heterotrimeric GTP-Binding Proteins / physiology
Interdisciplinary Communication
Models, Biological
Receptors, G-Protein-Coupled / physiology*
Signal Transduction / physiology*
Systems Biology*
Reg. No./Substance:
0/Ligands; 0/Receptors, G-Protein-Coupled; EC GTP-Binding Proteins

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