Document Detail


Towards regenerative therapy for cardiac disease.
MedLine Citation:
PMID:  22405796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of regenerative therapeutic strategies to reverse the progression of advanced heart failure is one of the most urgent clinical needs of this century. Insights gained from clinical trials of adult stem cells, together with fundamental scientific advances in cardiac stem cell and regenerative biology, are beginning to yield potential new targets and strategies for regenerative therapies. Of particular importance are new scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger regeneration, and tissue-engineering technology, which are beginning to change the way investigators view the scientific and clinical position of cardiovascular regenerative therapy.
Authors:
Leon M Ptaszek; Moussa Mansour; Jeremy N Ruskin; Kenneth R Chien
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lancet     Volume:  379     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-03-19     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  933-42     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Heart / physiology*
Heart Failure / therapy*
Humans
Myocytes, Cardiac / transplantation
Pluripotent Stem Cells / transplantation
Regeneration / physiology*
Stem Cell Transplantation* / methods
Tissue Engineering / methods
Transplantation, Autologous
Grant Support
ID/Acronym/Agency:
U01 HL100408/HL/NHLBI NIH HHS

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