Document Detail

Towards a nanoscale view of lactic acid bacteria.
MedLine Citation:
PMID:  22293169     Owner:  NLM     Status:  Publisher    
Probiotic bacteria have a strong potential in biomedicine owing to their ability to induce various beneficial health effects. Bacterial cell surface constituents play a key role in establishing tight interactions between probiotics and their host. Yet, little is known about the spatial organization and biophysical properties of the individual molecules. In this paper, we discuss how we have been using atomic force microscopy imaging and force spectroscopy to probe the nanoscale surface properties of Gram-positive lactic acid bacteria, with an emphasis on probiotic strains. Topographic imaging has enabled us to visualize bacterial cell surface structures (peptidoglycan, teichoic acids, pili, polysaccharides) under physiological conditions and with unprecedented resolution. In parallel, single-molecule force spectroscopy has been used to localize and force probe single cell surface constituents, providing novel insights into their spatial distribution and molecular elasticity.
Prachi Tripathi; Audrey Beaussart; Guillaume Andre; Thomas Rolain; Sarah Lebeer; Jos Vanderleyden; Pascal Hols; Yves F Dufrêne
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Micron (Oxford, England : 1993)     Volume:  -     ISSN:  1878-4291     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312850     Medline TA:  Micron     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Université catholique de Louvain, Institute of Condensed Matter and Nanosciences, Croix du Sud, 1, bte L7.04.01., B-1348 Louvain-la-Neuve, Belgium; K.U.Leuven, Centre of Microbial and Plant Genetics and INPAC, Kasteelpark Arenberg 20, Box 2460, B-3001 Leuven, Belgium.
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