| Towards molecular imaging of multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 21212087 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Magnetic resonance imaging (MRI) has had a profound impact on both research and clinical management of multiple sclerosis (MS), but signal changes reflect underlying neuropathology only indirectly and often non-specifically. Positron emission tomography (PET) offers the potential to complement MRI with quantitative measures of molecularly specific markers of cellular and metabolic processes. PET radiotracers already available promise new insights into the dynamics of the innate immune response, neuronal function, neurodegeneration and remyelination. Because PET is an exquisitely sensitive technique (able to image even picomolar concentrations), only microdoses of radioligand (<10 µg) are needed for imaging. This facilitates rapid implementation of novel radioligands because extensive toxicology data is not required. In the future, molecular imaging could assist clinical decision-making with patient stratification for optimization of treatment selection. |
| | |
Authors:
|
David Rj Owen; Paola Piccini; Paul M Matthews |
Related Documents
:
|
11390197 - Congenital anomalies of the pancreaticobiliary tract: findings on mr cholangiopancreato... 3118677 - Mr imaging artifacts produced by dental materials. 19859857 - A hybrid breath hold and continued respiration-triggered technique for time-resolved 3d... 10398957 - Gradient echo time dependence and quantitative parameter maps for somatosensory activat... 14753397 - Non-invasive imaging methods for the characterization of the pathophysiology of brain i... 20136647 - Efns guidelines on the use of neuroimaging in the management of motor neuron diseases. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-6 |
Journal Detail:
|
Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: - ISSN: 1477-0970 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Experimental Medicine, Imperial College, Hammersmith Hospital/GSK Clinical Imaging Centre, Hammersmith Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis.
Next Document: Temporal relationship between environmental Influenza A and Epstein-Barr viral infections and high m...