| Towards the mechanism of altered nutrients uptake in renal brush border membrane vesicles from pyelonephritic rats. | |
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MedLine Citation:
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PMID: 3454649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Affinity constant (Km) of D-glucose, L-alanine, L-aspartate, L-lysine, L-proline and nutrients coupled Na+ were determined in renal brush border membrane vesicles prepared from control and pyelonephritic rats. The Km of D-glucose, amino acids and nutrients coupled Na+ was noted to be significantly increased (p less than 0.001) in experimental animals. The Vmax of D-glucose and amino acids was determined at different concentrations of nutrients keeping extravesicular Na+ constant or at different concentrations of extravesicular Na+ keeping nutrient concentration constant. In the experimental rats the Vmax decreased significantly (p less than 0.01) when compared to control. The increased Km and decreased Vmax may be one of the underlying mechanism leading to decrease in the uptake of D-glucose and amino acids. |
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Authors:
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U C Garg; N K Ganguly; R Bhatnagar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry international Volume: 14 ISSN: 0158-5231 ISO Abbreviation: Biochem. Int. Publication Date: 1987 May |
Date Detail:
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Created Date: 1988-09-15 Completed Date: 1988-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100311 Medline TA: Biochem Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 949-55 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacokinetics* Animals Female Glucose / pharmacokinetics* Kidney / metabolism* Microvilli / metabolism Pyelonephritis / metabolism* Rats Rats, Inbred Strains Sodium / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 50-99-7/Glucose; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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