Document Detail


Towards lysozyme nanotube and 3D hybrid self-assembly.
MedLine Citation:
PMID:  23824259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report lysozyme self-assembly into nanotubes, under the effect of hydrolysis at pH 2 and 90 °C. We resolve the final steps of the fibrillation pathway, entailing the closure of multi-stranded helical ribbons into nanotubes, and we provide evidence of β-sheet arrangement within the nanotubes, demonstrating amyloid-like aggregation. Addition of chloroauric acid to the self-assembled structures can lead to generation of either gold single crystal nanoplatelets or gold nanoparticles (when a reducing agent is added) decorating the nanotube and ribbon surfaces. The crystal-based organic-inorganic hybrids further assemble into 3D "sandwiched" structures.
Authors:
Cecile Lara; Stephan Handschin; Raffaele Mezzenga
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-2
Journal Detail:
Title:  Nanoscale     Volume:  -     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Food and Soft Material Science, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 9, LFO, E23, 8092 Zürich, Switzerland. raffaele.mezzenga@hest.ethz.ch.
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