Document Detail

Towards improved animal models of neonatal white matter injury associated with cerebral palsy.
MedLine Citation:
PMID:  21030421     Owner:  NLM     Status:  MEDLINE    
Newborn neurological injuries are the leading cause of intellectual and motor disabilities that are associated with cerebral palsy. Cerebral white matter injury is a common feature in hypoxic-ischemic encephalopathy (HIE), which affects full-term infants, and in periventricular leukomalacia (PVL), which affects preterm infants. This article discusses recent efforts to model neonatal white matter injury using mammalian systems. We emphasize that a comprehensive understanding of oligodendrocyte development and physiology is crucial for obtaining new insights into the pathobiology of HIE and PVL as well as for the generation of more sophisticated and faithful animal models.
John C Silbereis; Eric J Huang; Stephen A Back; David H Rowitch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease models & mechanisms     Volume:  3     ISSN:  1754-8411     ISO Abbreviation:  Dis Model Mech     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-02-14     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101483332     Medline TA:  Dis Model Mech     Country:  England    
Other Details:
Languages:  eng     Pagination:  678-88     Citation Subset:  IM    
Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
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MeSH Terms
Biomedical Research
Cerebral Palsy / complications*,  pathology*
Disease Models, Animal*
Infant, Newborn
Leukomalacia, Periventricular / complications*,  pathology*
Oligodendroglia / pathology
Grant Support
//Howard Hughes Medical Institute

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