Document Detail


Towards elucidating the role of SirT1 in osteoarthritis.
MedLine Citation:
PMID:  23276927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteoarthritis (OA) is a degenerative joint disease particularly affecting the elderly population. Although several genetic features have been characterized as risk factors for OA susceptibility, a growing body of evidence indicates that epigenetic effectors may also modulate gene expression and thus contribute to OA pathology. One such epigenetic regulator of particular relevance to OA is Silent Information Regulator 2 type 1 (SirT1) which has been linked to aging and caloric intake, Consistently, SirT1 has been also connected with various age-associated diseases such as diabetes type II, Alzheimers and osteoporosis. Recent reports show that OA is linked to changes in SirT1 activity or levels within cartilage. In human chondrocytes, SirT1 plays a role in cartilage extracellular matrix (ECM) synthesis and promotes cell survival, even under proinflammatory stress. It appears that SirT1 fine tunes many cellular biochemical processes through its capacity to interact and modify various histone and non-histone proteins. Taken together these investigations demonstrate that SirT1 is involved in cartilage biology and could potentially serve as novel drug target in treating OA even at its premature stages, thereby possibly reversing mechanical-stress induced cartilage degeneration.
Authors:
Mona Dvir-Ginzberg; Juergen Steinmeyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-55     Citation Subset:  IM    
Affiliation:
Head Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University- Hadassah Ein Kerem P. O. Box 12272, Jerusalem 91120, Israel. monad@ekmd.huji.ac.il
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MeSH Terms
Descriptor/Qualifier:
Aged
Aggrecans / metabolism
Aging / physiology
Animals
Biomechanics
Cartilage, Articular / pathology,  physiology
Cell Survival
Chondrocytes / metabolism
Cytokines / metabolism
Epigenesis, Genetic
Extracellular Matrix / pathology
Female
Histones / metabolism
Humans
Male
Middle Aged
NAD / metabolism
Nicotinamide Phosphoribosyltransferase / metabolism
Osteoarthritis / genetics
Sirtuin 1 / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Aggrecans; 0/Cytokines; 0/Histones; 53-84-9/NAD; EC 2.4.2.12/Nicotinamide Phosphoribosyltransferase; EC 2.4.2.12/nicotinamide phosphoribosyltransferase, human; EC 3.5.1.-/SIRT1 protein, human; EC 3.5.1.-/Sirtuin 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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