| Towards drug discovery for brain tumours: interaction of kinins and tumours at the blood brain barrier interface. | |
| | |
MedLine Citation:
|
PMID: 21073431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cancers of the brain are intrinsically more complicated to treat than systemic malignancies due to the unique anatomical features of the brain. The blood-brain barrier prevents chemotherapeutic agents from reaching brain neoplasms, and angiogenesis occurs as the metabolic needs of the tumour increase, thus further complicating treatment. The newly formed blood vessels form the blood-tumour barrier and are distinct from the blood-brain barrier in that they are more permeable. Being more permeable, these abnormal blood vessels lead to the formation of peri-tumoural edema, which is the cause of much morbidity and mortality associated with central nervous system neoplasms. While the cause of the increased permeability is unclear, kinins have been implicated in regulating the permeability of normal vasculature. Kinins are also known to exert many inflammatory actions affecting both normal and angiogenic blood vessels, as well as tumour cells. The vasodilatory and vascular permeabilizing effects of kinins, and particularly bradykinin and substance P, have been investigated with regard to delivery of chemotherapeutic agents to neoplastic brain tissue through both vascular barriers. In contrast, kinin receptor antagonists have been found to exert effects on tumour cells that result in decreased angiogenesis, tumour cell motility and growth. Thus, many recent patents describe kinin activity on brain vasculature, which may play an integral role in the development of treatments for malignancies in the central nervous system through amelioration of angiogenesis. In conjunction, patents that discuss the ability of kinins to decrease tumour cell migration and proliferation demonstrate that kinins may offer novel approaches to brain tumour therapy in the future. |
| | |
Authors:
|
Elizabeth Harford-Wright; Kate M Lewis; Robert Vink |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Recent patents on CNS drug discovery Volume: 6 ISSN: 2212-3954 ISO Abbreviation: Recent Pat CNS Drug Discov Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-04-14 Revised Date: 2011-11-10 |
Medline Journal Info:
|
Nlm Unique ID: 101265656 Medline TA: Recent Pat CNS Drug Discov Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 31-40 Citation Subset: IM |
Affiliation:
|
Adelaide Centre for Neuroscience Research, and the Discipline of Anatomy and Pathology, University of Adelaide, Adelaide, South Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiogenesis Modulating Agents
/
metabolism,
pharmacology,
therapeutic use Blood-Brain Barrier / drug effects*, metabolism Brain Neoplasms / blood supply, drug therapy*, metabolism Disease Progression Drug Discovery* Humans Kinins / metabolism, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Angiogenesis Modulating Agents; 0/Kinins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Future targeted disease modifying drugs for Alzheimer's disease.
Next Document: Recent developments in therapeutic approaches for lysosomal storage diseases.