Document Detail

Towards defining adequate lithium trials for individuals with mental retardation and mental illness.
MedLine Citation:
PMID:  2059418     Owner:  NLM     Status:  MEDLINE    
Lithium has been recommended for some psychiatric conditions and/or behavior disturbances in patients with mental retardation. Components of an adequate clinical trial were described here and case studies and double-blind cases reviewed. Based on existing data, there are few guidelines for the use of lithium with this population. Of the various indicators for lithium, the most solid are for aggression, although the type of aggression is not specified: (a) achieve a serum concentration of at least 0.5 mEq/1 to 1.0 mEq/1 unless the patient responds or trial-ending side effects appear and (b) treat for 6 to 8 weeks before concluding that the patient will not respond.
R J Pary
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of mental retardation : AJMR     Volume:  95     ISSN:  0895-8017     ISO Abbreviation:  Am J Ment Retard     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8800463     Medline TA:  Am J Ment Retard     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-91     Citation Subset:  IM    
Dual Diagnosis Program, University of Pittsburgh School of Medicine, PA 15213.
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MeSH Terms
Aggression / drug effects
Lithium / adverse effects,  pharmacokinetics,  therapeutic use*
Mental Retardation / drug therapy*,  psychology
Mood Disorders / drug therapy*,  psychology
Psychomotor Agitation / drug therapy,  psychology
Reg. No./Substance:

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