Document Detail

Towards creating a superstimulus to normalise glucose metabolism in the prediabetic: a case-study in the feast-famine and activity-rest cycle.
MedLine Citation:
PMID:  22605804     Owner:  NLM     Status:  MEDLINE    
We live in a time of plenty. During evolution, periods of hunger and simultaneously high activity levels would combine giving a stimulus which is absent from modern lifestyles. This is potentially connected with abnormal glucose metabolism. It was hypothesised that simultaneous fasting and aggressive aerobic neuromuscular electrical stimulation (NMES) exercise, until metabolic exhaustion, may be an acceptable modern equivalent. A healthy subject fasted for 44 h (water allowed) during which he undertook three aerobic NMES sessions at >50%VO(2max); heart rate >160 bpm. Metabolic gas analysis of a comparable session in the non-fasting state showed 100% carbohydrate substrate utilisation. With fasting the NMES exercise consumed mostly fat-up to 100% fat utilisation at 42 h. This clear shift away from using carbohydrate as a substrate and hypoglycaemia may indicate that carbohydrate stores are nearly depleted. The authors postulate that this may constitute a metabolic super stimulus mimicking the famine-activity periods of our ancestors.
Louis Crowe; Brian Caulfield
Related Documents :
24898534 - Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.
23816984 - Central administration of prolactin-releasing peptide shifts the utilities of metabolic...
3963434 - The effect of cimetidine on anesthetic metabolism and toxicity.
22882604 - Anaesthetic complications in pigs undergoing mri guided convection enhanced drug delive...
9268044 - Cytogenetic effects of x-rays in the guinea pig female germ cells. i. the immature oocyte.
522514 - Absorption and metabolism of naphthalene and benzo(a)pyrene in the rat jejunum in situ.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-27
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Absorptiometry, Photon
Diabetes Mellitus, Type 2 / metabolism*,  prevention & control*
Energy Metabolism
Exercise / physiology*
Fasting / metabolism*
Glucose / metabolism*
Prediabetic State / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multidrug-resistant tuberculosis that required 2 years for diagnosis.
Next Document:  Flash pulmonary oedema: a rare but serious side effect of quinine sulphate.