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Towards Systems Biology of Pulmonary Hypertension.
MedLine Citation:
PMID:  22371329     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this issue of Circulation, Parikh and colleagues(1) present an elegant study that lies at the intersection of two recent major developments in cardiovascular research - the recognition of the role of microRNAs in normal and abnormal cardiovascular biology, and the introduction of computational systems biology approaches to elucidate the mechanisms of cardiovascular disease. This work provides convincing evidence for the central role of microRNA-21 (miR-21) in the pathogenesis of pulmonary hypertension (PH) generally and pulmonary arterial hypertension (PAH) more specifically, and suggests a potential "two-hit" rationale for incomplete penetrance of mutations in BMPR2 in heritable PAH. (SELECT FULL TEXT TO CONTINUE).
Authors:
Ferhaan Ahmad; Hunter C Champion; Naftali Kaminski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-27
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Pittsburgh, Pittsburgh, PA.
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