Document Detail


Toward a nonhuman primate model of fetal programming: phenotypic plasticity of the common marmoset fetoplacental complex.
MedLine Citation:
PMID:  22776637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonhuman primates offer unique opportunities as animal models in the study of developmental programming and the role of the placenta in developmental processes. All primates share fundamental similarities in life history and reproductive biology. Thus, insights gleaned from studies of nonhuman primates have a higher degree of biological salience to human biology than do studies of rodents or agricultural animals. The common marmoset monkey is a small-bodied primate from South America that produces litters of dizygotic fetuses that share a single placental mass. This natural variation allows us to model different intrauterine conditions and associated fetoplacental phenotypes. The marmoset placenta is phenotypically plastic according to litter size. Triplet litters are characterized by low individual fetal weights and significantly more efficient placentas and attendant alterations to the microscopic architecture and endocrine function, thus modeling a nutrient restricted intrauterine environment. Consistent with this model, triplet neonates experience a higher risk of perinatal mortality and an increased likelihood of elevated adult weight. Recent evidence has shown that the intrauterine experience of females has an impact on their own pregnancy outcomes in adulthood: triplet females experience significantly greater pregnancy loss than do twin females. The marmoset monkey thus represents a potential powerful nonhuman primate model of multiple pregnancies, restrictive prenatal experiences, and differential reproductive outcomes in adulthood, which may have important implications for studying the impact of in vitro fertilization on adult reproductive health. It is still too early to determine exactly what developmental pathways lead to this disparity or what specific role the placenta plays; future work on this front will be critical to establish the marmoset as an important model of fetal programming of reproductive function in adulthood and across generations.
Authors:
Julienne N Rutherford
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-07
Journal Detail:
Title:  Placenta     Volume:  33 Suppl 2     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-04-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  e35-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Oral Biology, College of Dentistry, Comparative Primate Biology Laboratory, University of Illinois at Chicago, 801 S. Paulina Street, M/C 690, Chicago, IL 60612, USA. ruther4d@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Callithrix*
Female
Fetal Development*
Litter Size / physiology
Models, Animal*
Placenta / physiology*
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple / physiology
Prenatal Exposure Delayed Effects
Grant Support
ID/Acronym/Agency:
K12 HD055892/HD/NICHD NIH HHS; K12HD055892/HD/NICHD NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51-RR13986/RR/NCRR NIH HHS; R01-DK77639/DK/NIDDK NIH HHS; R01-RR02022/RR/NCRR NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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