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Toward the non-invasive determination of cerebral perfusion pressure.
MedLine Citation:
PMID:  20330220     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Brains subjected to blast from an explosive or other sources of trauma often develop intracranial hemorrhage or edema or loose their ability to autoregulate the blood flowing into the brain (cerebral autoregulation). Such damage can, in turn, lead to increases in intracranial pressure (ICP) and decreases in cerebral perfusion pressure (CPP=arterial blood pressure-ICP) that, in turn, can lead to ischemia andor herniation, and brain death. This is not good for the patient. To assay ICP, of intrinsic value, and CPP-two variables of critical interest to the medical staff who treat and manage patients with head injury-requires a (invasive) neurosurgical procedure. Here I describe research performed over the last several years whose target is the prediction of ICP and CPP using arterial blood pressure data as well as data derived from transcranial Doppler. In particular, I will review the process by which we collected sufficient human-derived data in order to make a decent pass at predicting ICP for patients with closed traumatic brain injury (TBI) and a great effort at predicting CPP for these and a complementary group of patients.
Authors:
Pierre D Mourad
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  127     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1789     Citation Subset:  IM    
Affiliation:
Appl. Phys. Lab., Univ. of Washington, 1013 NE 40th St., Seattle, WA 98105, pierre@apl.washington.edu.
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