Document Detail

Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance.
MedLine Citation:
PMID:  21399919     Owner:  NLM     Status:  Publisher    
The primary function assigned to the sodium-dependent glutamate transporters, also known as excitatory amino acid transporters (EAATs), is to maintain the extracellular glutamate concentration in the low micromolar range, allowing glutamate to be used as a signaling molecule in the brain and preventing its cytotoxic effects. However, glutamate and cyst(e)ine, that is also a substrate of EAATs, are also important metabolites used for instance in the synthesis of the main antioxidant glutathione. This review describes the evidence suggesting that EAATs, by providing glutathione precursors, are crucial to prevent oxidative death in particular cells of the nervous system while being dispensable in others. This differential importance may depend on the way antioxidant defenses are maintained in each cell type and on the metabolic fate of transported substrates, both being probably controlled by EAAT interacting proteins. As oxidative stress invariably contributes to various forms of cell death, a better understanding of how antioxidant defenses are maintained in particular brain cells will probably help to develop protective strategies in degenerative insults specifically affecting these cells.
Laurence Had-Aissouni
Related Documents :
20420809 - Tgf-beta superfamily regulates a switch that mediates differentiation either into adipo...
16860319 - Galpha13 activation rescues moesin-depletion induced apoptosis in f9 teratocarcinoma ce...
12972299 - Differential expression of versican isoforms is a component of the human melanoma cell ...
19229869 - Exogenous nanog alleviates but is insufficient to reverse embryonic stem cells differen...
8518229 - Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ml-1 h...
21369939 - The transsulfuration pathway: a source of cysteine for glutathione in astrocytes.
23639509 - Mechanisms of apple polyphenols-induced proliferation inhibiting and apoptosis in a met...
23667549 - Stem cells derived from neonatal mouse kidney generate functional proximal tubule-like ...
6480449 - Survival in subpopulations of cells derived from solid kht sarcomas by centrifugal elut...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-12
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Developmental Biology Institute of Marseille-Luminy, CNRS/Aix-Marseille University, Marseille Campus de Luminy Case 907, 13288, Marseille cedex 9, France,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Creatine as a therapeutic strategy for myopathies.
Next Document:  Watermelon chlorotic stunt virus (WmCSV): a serious disease threatening watermelon production in Jor...