| Toward a multiscale model of antigen presentation in immunity. | |
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MedLine Citation:
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PMID: 17367337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II-mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines. |
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Authors:
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Denise E Kirschner; Stewart T Chang; Thomas W Riggs; Nicolas Perry; Jennifer J Linderman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunological reviews Volume: 216 ISSN: 0105-2896 ISO Abbreviation: Immunol. Rev. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-05-17 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 93-118 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. kirschne@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation* Antigen-Presenting Cells / immunology* Histocompatibility Antigens Class II / immunology* Humans Immunity, Cellular* Models, Immunological* |
| Grant Support | |
ID/Acronym/Agency:
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HL68526/HL/NHLBI NIH HHS; HL72682/HL/NHLBI NIH HHS; LM00902701/LM/NLM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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