Document Detail

Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling.
MedLine Citation:
PMID:  25249277     Owner:  NLM     Status:  Publisher    
The ability of using non-expensive ultrasound (US) image data together with computer fluid simulation to access various severities of carotid stenosis was inquired in this study. Subject-specific hemodynamic conditions were simulated using a developed finite element solver. Individual structured meshing of the common carotid artery (CCA) bifurcation was built from segmented longitudinal and cross-sectional US images; imposed boundary velocities were based on Doppler US measurements. Simulated hemodynamic parameters such as velocities, wall shear stress (WSS) and derived descriptors were able to predict disturbed flow conditions which play an important role in the development of local atherosclerotic plaques. Hemodynamic features from six individual CCA bifurcations were analyzed. High values of time-averaged WSS (TAWSS) were found at stenosis site. Low values of TAWSS were found at the bulb and at the carotid internal and external branches depending on the particular features of each patient. High oscillating shear index and relative residence time values assigned highly disturbed flows at the same artery surface regions that correlate only moderately with low TAWSS results. Based on clinic US examinations, results provide estimates of flow changes and forces at the carotid artery wall toward the link between hemodynamic behavior and stenosis pathophysiology.
Luísa C Sousa; Catarina F Castro; Carlos C António; André Miguel F Santos; Rosa Maria Dos Santos; Pedro Miguel A C Castro; Elsa Azevedo; João Manuel R S Tavares
Related Documents :
17271117 - Dynamic response of the pulmonary circulation in continuous flow artificial heart systems.
3631647 - Right atrial thrombus and recurrent pulmonary emboli secondary to permanent cardiac pac...
1157287 - Left atrial appendage aneurysm: correlation of noninvasive with clinical and surgical f...
10731487 - Increased left atrial thrombin generation in mitral stenosis is not reflected in arteri...
2555527 - Effect of atrial natriuretic factor on angiotensin converting enzyme.
24046437 - Spontaneous limb movements and posturing secondary to acute basilar artery occlusion: a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-24
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  -     ISSN:  1741-0444     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-24     Completed Date:  -     Revised Date:  2014-9-25    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gaitography applied to prosthetic walking.
Next Document:  A Review on the Mechanisms of Blood-Flow Restriction Resistance Training-Induced Muscle Hypertrophy.