| Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder. | |
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MedLine Citation:
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PMID: 21901425 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Child and adolescent psychiatric neuroimaging research typically lags behind similar advances in adult disorders. While the pediatric depression imaging literature is less developed, a recent surge in interest has created the need for a synthetic review of this work. Major findings from pediatric volumetric and functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and resting state functional connectivity studies converge to implicate a corticolimbic network of key areas that work together to mediate the task of emotion regulation. Imaging the brain of children and adolescents with unipolar depression began with volumetric studies of isolated brain regions that served to identify key prefrontal, cingulate and limbic nodes of depression-related circuitry elucidated from more recent advances in DTI and functional connectivity imaging. Systematic review of these studies preliminarily suggests developmental differences between findings in youth and adults, including prodromal neurobiological features, along with some continuity across development. |
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Authors:
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Leslie A Hulvershorn; Kathryn Cullen; Amit Anand |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-8 |
Journal Detail:
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Title: Brain imaging and behavior Volume: - ISSN: 1931-7565 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300405 Medline TA: Brain Imaging Behav Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Mood and Emotional Disorders Across the Lifespan Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, lhulvers@iupui.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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