Document Detail

Toward development of a surface-enhanced Raman scattering (SERS)-based cancer diagnostic immunoassay panel.
MedLine Citation:
PMID:  23150876     Owner:  NLM     Status:  MEDLINE    
Proteomic analyses of readily obtained human fluids (e.g., serum, urine, and saliva) indicate that the diagnosis of complex diseases will be enhanced by the simultaneous measurement of multiple biomarkers from such samples. This paper describes the development of a nanoparticle-based multiplexed platform that has the potential for simultaneous read-out of large numbers of biomolecules. For this purpose, we have chosen pancreatic adenocarcinoma (PA) as a test bed for diagnosis and prognosis. PA is a devastating form of cancer in which an estimated 86% of diagnoses resulted in death in the United States in 2010. The high mortality rate is due, in part, to the asymptomatic development of the disease and the dearth of sensitive diagnostics available for early detection. One promising route lies in the development of a serum biomarker panel that can generate a signature unique to early stage PA. We describe the design and development of a proof-of-concept PA biomarker immunoassay array coupled with surface-enhanced Raman scattering (SERS) as a sensitive readout method.
Jennifer H Granger; Michael C Granger; Matthew A Firpo; Sean J Mulvihill; Marc D Porter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Analyst     Volume:  138     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2014-01-10     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  410-6     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / diagnosis*
CA-19-9 Antigen / blood*
Gold / diagnostic use
Matrix Metalloproteinase 7 / blood*
Metal Nanoparticles / diagnostic use
Pancreatic Neoplasms / diagnosis*
Spectrum Analysis, Raman*
Tumor Markers, Biological / blood
Grant Support
P30CA042014/CA/NCI NIH HHS; R33 CA155586/CA/NCI NIH HHS; R33CA155586/CA/NCI NIH HHS; U01 CA151650/CA/NCI NIH HHS; U01CA151650/CA/NCI NIH HHS
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Tumor Markers, Biological; 7440-57-5/Gold; EC protein, human; EC Metalloproteinase 7

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