| Toward the development of a sensitive, pre-clinical screen for neurological diseases from spontaneous neural coordination in juvenile and young-adult C57BK6 mice. | |
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MedLine Citation:
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PMID: 20080150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous Frequency Bursts (SFBs) are a newly discovered form of long-distance neural coordination. They have several distinctive properties, including near-simultaneity of occurrence (+/-25-50 ms) across distant brain regions and high within- and across-site coherence in multiple low and high frequency bands, presumably requiring high axonal, dendritic and vascular integrity. We examined whether SFBs occurred in young and young-adult C57BK6 mice with properties similar to those seen in rats. We found that across the entorhinal and piriform cortices, SFBs occur robustly in young and young-adult mice under light anesthesia, and that their rate of occurrence dropped sharply as anesthetic levels increased, as in rats. Moreover, murine SFBs showed high cross-site coherence in multiple frequency bands, including those that require exquisite action potential timing to be maintained across long distances. We discuss our findings in light of SFBs potential as a pre-clinical biomarker for diseases affecting action potential firing and local field potential coherence, especially in high frequency ranges (20-30 Hz and beyond). |
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Authors:
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Jordan Robson; Nisarg Mehta; Jeanette E Polcz; Linda Hermer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
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Title: Neuroscience letters Volume: 471 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 74-8 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Behavioral Neuroscience Program, Department of Psychology, University of Florida, Gainesville, FL 32611, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Aging / physiology* Anesthesia Animals Brain / physiology* Male Mice Mice, Inbred C57BL Nervous System Diseases / physiopathology* |
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