| Toward the delineation of mania subtypes in the French National EPIMAN-II Mille Cohort. Comparisons with prior cluster analytic investigations. | |
| | |
MedLine Citation:
|
PMID: 18574610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Knowledge about psychopathologic presentations of mania in current clinical practice has to be refined in order to improve diagnosis and treatment. METHODS: One thousand ninety manic patients included in the French National Study EPIMAN-II Mille were submitted to a cluster analysis on the basis of multiple variables related to the history of bipolar illness and symptoms of the current episode. RESULTS: Four clusters were identified: "classic mania" (29.3% of patients) with less severe mania; "psychotic mania" (22.7%) with psychotic symptoms, more severe mania, younger age and social impairment; "depressive mania" (30.4%) characterized by female gender, suicide attempts, high number of previous episodes and residual symptoms; and "dual mania" (17.6%) characterized by male gender, substance use, earlier onset and poor compliance. Patients groups also differed in manic symptoms, marital status, stressors preceding illness onset, prior diagnoses, first episode polarity and temperamental characteristics. LIMITATIONS: Cross-sectional assessment of patients. CONCLUSIONS: In comparing our findings with those of four prior cluster analytic studies, we integrate clinical characteristics of mania subtypes found in this very large representative French sample in contemporary practice, we suggest how such convergence of data may help improve earlier recognition, differential response to different treatments, and prevention of these subtypes. We finally suggest that such subtyping might provide clues to phenotype delineation suitable for pharmacogenetic investigations. |
| | |
Authors:
|
Jean-Michel Azorin; Arthur Kaladjian; Marc Adida; Elie Hantouche; Ahcene Hameg; Sylvie Lancrenon; Hagop Souren Akiskal |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-20 |
Journal Detail:
|
Title: European archives of psychiatry and clinical neuroscience Volume: 258 ISSN: 1433-8491 ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2009-01-13 Completed Date: 2009-03-02 Revised Date: 2009-05-11 |
Medline Journal Info:
|
Nlm Unique ID: 9103030 Medline TA: Eur Arch Psychiatry Clin Neurosci Country: Germany |
Other Details:
|
Languages: eng Pagination: 497-504 Citation Subset: IM |
Affiliation:
|
Adult Psychiatry Department, Ste Marguerite Hospital, 270 Bd Sainte-Marguerite, 13274 Marseille Cedex 09, France. jazorin@ap-hm.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Analysis of Variance Bipolar Disorder / classification*, diagnosis*, psychology Cluster Analysis Cohort Studies Female France Humans Male Middle Aged Patient Compliance / psychology, statistics & numerical data Severity of Illness Index Sex Factors Social Behavior Substance-Related Disorders / psychology Suicide, Attempted / psychology, statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depress...
Next Document: Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological asses...