| Toward a better understanding of preeclampsia: Comparative proteomic analysis of preeclamptic placentas. | |
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MedLine Citation:
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PMID: 21136660 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Preeclampsia (PE), a pregnancy-specific syndrome of hypertension, proteinuria, and other systemic disturbances, is a state of widespread endothelial dysfunction secondary to defective placentation. Morphologically, the current data displayed degenerative and apoptotic changes in the mitochondria and villous trophoblasts of preeclamptic placenta. To reveal the superimposing alterations in placental proteins that might explain the pathophysiology of PE, we performed 2-DE MALDI-TOF MS/MS proteomics analysis of differentially expressed placental proteins with placenta from eight normal and eight preeclamptic pregnancies. The identified proteins were confirmed by Western blot analysis. We also performed morphologic evaluation of preeclamptic placentas under both electron and light microscopy. The results disclosed the marked overexpression of chaperonin 60, GST, VDAC, ERp29, and cathepsin D in PE. These proteomics findings clearly suggest the possible cellular battle against mitochondria-originated oxidative stress during PE that either end up with recovery or apoptosis. These results provide a better understanding of proteomic alterations and may help in clarification of stress-related changes in preeclamptic placentas. |
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Authors:
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Young Nam Kim; Hyoung Kyu Kim; Mohamad Warda; Nari Kim; Won Sun Park; Ab Del Bary Prince; Dae Hoon Jeong; Dae Shim Lee; Ki Tae Kim; Jin Han |
Publication Detail:
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Type: Journal Article Date: 2007-11-16 |
Journal Detail:
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Title: Proteomics. Clinical applications Volume: 1 ISSN: 1862-8346 ISO Abbreviation: Proteomics Clin Appl Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2010-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101298608 Medline TA: Proteomics Clin Appl Country: Germany |
Other Details:
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Languages: eng Pagination: 1625-36 Citation Subset: - |
Copyright Information:
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Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Korea; Paik Institute for Clinical Research, College of Medicine, Inje University, Busan, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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