Document Detail


Toward an animal model of childhood-onset obesity: follow-up of OLETF rats during pregnancy and lactation.
MedLine Citation:
PMID:  19036826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat model of obesity (a spontaneous CCK1 receptor knockout) has been extensively studied as model of hyperphagia-induced obesity. In previous studies, young OLETF rats presented abnormal eating patterns [compared with Long-Evans Tokushima Otsuka (LETO) controls] in a variety of independent ingestion and nursing tests during the suckling period. The aim of the present study was to characterize the early emergence of abnormal adiposity in the pups. Moreover, because both the dams and the pups present the genetic mutation, a close follow-up of the dams' body weight and intake during pregnancy and lactation was performed to examine the circumstances that contribute to build up the pups' early adiposity. Compared with controls, OLETF pups presented higher fat levels, larger adipocytes, and increased waist circumference as early as postnatal day 7 and this profile persisted to the age of weaning. While LETO dams gained weight throughout pregnancy and lactation, OLETF dams were obese and hyperphagic during pregnancy but lost weight during lactation, probably as a result of rearing hyperphagic pups. Current and previous results suggest a possible influence of the dams' obesity during gestation and a high investment in nursing time during lactation on the pups' obesity levels during childhood. This, combined with the innate hyperphagia repeatedly observed in the pups at these early ages, makes the OLETF strain a useful tool in the research of childhood-onset obesity.
Authors:
Mariana Schroeder; Liat Shbiro; Orna Zagoory-Sharon; Timothy H Moran; Aron Weller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-11-26
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-12     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R224-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / pathology
Adipose Tissue, Brown / pathology
Adiposity* / genetics
Age Factors
Age of Onset
Aging
Animal Nutritional Physiological Phenomena
Animals
Animals, Newborn
Animals, Suckling
Body Mass Index
Body Weight
Disease Models, Animal*
Energy Intake
Feeding Behavior
Female
Hyperphagia / physiopathology
Lactation*
Leptin / blood
Male
Maternal Nutritional Physiological Phenomena
Obesity / genetics,  metabolism,  pathology,  physiopathology*
Pregnancy
Pregnancy, Animal*
Prenatal Exposure Delayed Effects*
Rats
Rats, Inbred OLETF
Receptor, Cholecystokinin A / genetics
Weaning
Grant Support
ID/Acronym/Agency:
R01 DK057609/DK/NIDDK NIH HHS; R01 DK057609-08/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 0/Receptor, Cholecystokinin A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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