Document Detail

Toward an analogue of alcoholism in mice: scale factors in the model.
MedLine Citation:
PMID:  6587369     Owner:  NLM     Status:  MEDLINE    
Mice of the C57BL strain, given continuous access to 10% alcohol and plain water, with unlimited food and no stress, frequently drink enough alcohol to produce intoxicating levels in the blood. Nevertheless, this behavior does not appear to replicate the essential features of human alcoholism since the drinking lacks serious toxic effects and the intoxication occurs only as transient episodes in association with homeostatic consumption of fluid and food. It is suggested that continuous monitoring of intake and estimation of the concentration of alcohol in blood, which are now technically feasible, will permit distinction between alcoholic-type drinking and a simple licking for the flavor of alcohol in beverage concentration.
V P Dole; R T Gentry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  81     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-24     Completed Date:  1984-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3543-6     Citation Subset:  IM    
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MeSH Terms
Alcoholism / metabolism*
Body Weight
Disease Models, Animal*
Ethanol / blood,  metabolism*
Metabolic Clearance Rate
Mice, Inbred C57BL
Tissue Distribution
Reg. No./Substance:

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