| Toward ambulatory arteriovenous CO2 removal: initial studies and prototype development. | |
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MedLine Citation:
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PMID: 14524565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracorporeal arteriovenous carbon dioxide removal (AVCO2R) using percutaneous cannulae and a low resistance gas exchanger achieves near total CO2 removal, allowing lung rest and potentially improving survival. AVCO2R, redesigned to allow ambulation, has potential as treatment for severe chronic obstructive pulmonary disease or rehabilitation before lung transplant. The purposes of this study were to 1) determine the optimal ambulatory access for AVCO2 removal and 2) develop a prototype Ambulatory-AVCO2R gas exchanger. Initially, reinforced Gore-Tex 6 mm (two) and 8 mm (four) grafts were anastomosed to sheep carotid arteries and jugular veins as a loop in parallel to the cranial circulation to determine blood flow capabilities. Blood flow was 100-150 ml/min with a 14 gauge dialysis needle, and transected 6 mm Gore-Tex grafts achieved 500-900 ml blood flow, whereas transected 8 mm grafts achieved up to 2000 ml/min flow. The polytetrafluoroethylene (PTFE) loops were then connected to our newly developed ultra low resistance pumpless gas exchanger for ambulatory AVCO2R. The average pressure gradient across the prototype Ambulatory-AVCO2R gas exchangers (n = 5) was 2.8 +/- 0.8 mm Hg, and mean CO2 removal was 104.8 +/- 14.0 ml/min, with an average blood flow of 900 ml/min. We conclude that an 8 mm Gore-Tex reinforced graft arteriovenous loop supplies ample blood flow for our new ultra low resistance Ambulatory-AVCO2R to achieve near total CO2 removal. |
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Authors:
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Dongfang Wang; Scott Lick; Scott K Alpard; Donald J Deyo; Clare Savage; Alex Duarte; Sean Chambers; Joseph B Zwischenberger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 49 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2003-10-03 Completed Date: 2004-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 564-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555-0528, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriovenous Shunt, Surgical* Carbon Dioxide / metabolism* Extracorporeal Membrane Oxygenation / instrumentation*, methods* Motor Activity Pilot Projects Polytetrafluoroethylene Sheep |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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