Document Detail


Toward an injectable continuous osmotic glucose sensor.
MedLine Citation:
PMID:  20663452     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The growing pandemic of diabetes mellitus places a stringent social and economic burden on the society. A tight glycemic control circumvents the detrimental effects, but the prerogative is the development of new more effective tools capable of longterm tracking of blood glucose (BG) in vivo. Such discontinuous sensor technologies will benefit from an unprecedented marked potential as well as reducing the current life expectancy gap of eight years as part of a therapeutic regime.
METHOD: A sensor technology based on osmotic pressure incorporates a reversible competitive affinity assay performing glucose-specific recognition. An absolute change in particles generates a pressure that is proportional to the glucose concentration. An integrated pressure transducer and components developed from the silicon micro- and nanofabrication industry translate this pressure into BG data.
RESULTS: An in vitro model based on a 3.6 x 8.7 mm large pill-shaped implant is equipped with a nanoporous membrane holding 4-6 nm large pores. The affinity assay offers a dynamic range of 36-720 mg/dl with a resolution of +/-16 mg/dl. An integrated 1 x 1 mm(2) large control chip samples the sensor signals for data processing and transmission back to the reader at a total power consumption of 76 microW.
CONCLUSIONS: Current studies have demonstrated the design, layout, and performance of a prototype osmotic sensor in vitro using an affinity assay solution for up to four weeks. The small physical size conforms to an injectable device, forming the basis of a conceptual monitor that offers a tight glycemic control of BG.
Authors:
Erik Johannessen; Olga Krushinitskaya; Andrey Sokolov; Häfliger Philipp; Arno Hoogerwerf; Christian Hinderling; Kari Kautio; Jaakko Lenkkeri; Esko Strömmer; Vasily Kondratyev; Tor Inge Tønnessen; Tom Eirik Mollnes; Henrik Jakobsen; Even Zimmer; Bengt Akselsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  4     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  882-92     Citation Subset:  IM    
Copyright Information:
2010 Diabetes Technology Society.
Affiliation:
Vestfold University College, Tønsberg, Norway. eaj@hive.no
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Aluminum Oxide
Automatic Data Processing
Blood Glucose / analysis*
Blood Glucose Self-Monitoring / instrumentation*
Diabetes Mellitus / blood*
Humans
Indicators and Reagents
Membranes, Artificial
Monitoring, Ambulatory / instrumentation*
Nanotechnology
Osmosis
Prostheses and Implants
Reproducibility of Results
Ultrafiltration
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Indicators and Reagents; 0/Membranes, Artificial; 1344-28-1/Aluminum Oxide
Comments/Corrections

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