| Toward Automated Oligosaccharide Synthesis. | |
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MedLine Citation:
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PMID: 22127846 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Carbohydrates have been shown to play important roles in biological processes. The pace of development in carbohydrate research is, however, relatively slow due to the problems associated with the complexity of carbohydrate structures and the lack of general synthetic methods and tools available for the study of this class of biomolecules. Recent advances in synthesis have demonstrated that many of these problems can be circumvented. In this Review, we describe the methods developed to tackle the problems of carbohydrate-mediated biological processes, with particular focus on the issue related to the development of the automated synthesis of oligosaccharides. Further applications of carbohydrate microarrays and vaccines to human diseases are also highlighted. |
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Authors:
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Che-Hsiung Hsu; Shang-Cheng Hung; Chung-Yi Wu; Chi-Huey Wong |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-30 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan); Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica (Taiwan); Institute of Bioinformatics and Structural Biology, National Tsing-Hua University, Hsin-Chu (Taiwan). |
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