| Tourette's syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder? | |
| | |
MedLine Citation:
|
PMID: 8083136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To explore the influence of gender and comorbid obsessive-compulsive disorder (OCD) on the phenomenology of Tourette's syndrome (TS). METHOD: TS proband groups defined by gender and comorbid OCD status were compared on a variety of sociodemographic variables, clinical characteristics, and perinatal complications. RESULTS: Compared to females, males more often onset with rage and had ever experienced any form of simple tics. Females onset with compulsive tics more often than males. Probands with comorbid OCD were more likely than those without OCD to onset with complex tics. Delivery complications, especially forceps deliveries, were associated with being male and with having OCD. Fetal exposure to relatively high levels of coffee, cigarettes, or alcohol predicted OCD in TS probands. Diagnosis of TS occurred at later ages among females than among males. Males and females displayed different age distributions. CONCLUSIONS: Males and females tend to experience different kinds of symptoms at onset. However, the overall experience of TS appears to be similar for both groups. Perinatal brain injury is implicated in the etiology of TS in some boys. Early brain injury may cause or exacerbate the development of OCD in some TS sufferers. |
| | |
Authors:
|
S L Santangelo; D L Pauls; J M Goldstein; S V Faraone; M T Tsuang; J F Leckman |
Related Documents
:
|
11722316 - Associations between childhood living circumstances and schizophrenia: a population-bas... 18076536 - Cognitive impairment in later life in patients with early-onset bipolar disorder. 15954196 - Developmental pathology, dopamine, and stress: a model for the age of onset of schizoph... 11229996 - Evidence of a cohort effect for age at onset of schizophrenia. 7896586 - Beta-adrenergic effects on left ventricular filling: influence of aging and exercise tr... 20031016 - Does age at orchidopexy impact on the results of testicular sperm extraction? |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of the American Academy of Child and Adolescent Psychiatry Volume: 33 ISSN: 0890-8567 ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Publication Date: 1994 Jul-Aug |
Date Detail:
|
Created Date: 1994-10-11 Completed Date: 1994-10-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8704565 Medline TA: J Am Acad Child Adolesc Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 795-804 Citation Subset: IM |
Affiliation:
|
Department of Epidemiology, Harvard Program in Psychiatric Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Age of Onset Brain Injuries / complications Child Female Humans Male Middle Aged Obsessive-Compulsive Disorder / complications*, etiology Obstetric Labor Complications Pregnancy Prenatal Exposure Delayed Effects Psychiatric Status Rating Scales Sex Factors Tic Disorders Tourette Syndrome / complications*, diagnosis, etiology |
| Grant Support | |
ID/Acronym/Agency:
|
MH 17119-10/MH/NIMH NIH HHS; MH00508/MH/NIMH NIH HHS; MH49351/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clonazepam as an augmenting agent in the treatment of childhood-onset obsessive-compulsive disorder.
Next Document: Premonitory urges as "attentional tics" in Tourette's syndrome.