Document Detail

Tourette syndrome and excitatory substances: is there a connection?
MedLine Citation:
PMID:  21057956     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND PURPOSE: The objective of this study is to investigate the relationship between excitatory substances by testing the urine in children with Tourette syndrome (TS).
METHODS: We performed a control study involving 44 patients with TS and 44 normal children by investigating the children's daily eating habits. We used the gas chromatograph-mass spectrometer and liquid chromatograph-mass spectrometer from Agilent. Substances for detection included 197 excitatory substances prohibited by the International Olympic Committee and other substances with similar chemical structures or biological functions for urine samples.
RESULTS: Forty-four patients who did not take any drugs in the past 2 weeks enrolled in the study. The positive rate in the experiment group was three cases, while it was negative in the control group. The level of 1-testosterone increased in one extremely severe TS patient who ate large amounts of puffed food and drank an average of 350 ml of cola per day. Cathine and other substances with similar chemical constitution or similar biological effects increased in one severe TS patient who ate bags of instant noodles daily, according to the high score of the Yale Global Tic Severity Scale.
CONCLUSION: An increase in ephedrine type, testosterone, and stimulants may be related to the pathogenesis of TS. Unhealthy food possibly causes TS. The relationship between excitatory substances and TS needs to be explored with the goal of providing more information on diagnosing and treating TS.
Li-Ping Zou; Ying Wang; Li-Ping Zhang; Jian-Bo Zhao; Jin-Fang Lu; Qun Liu; Hang-Yan Wang
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Publication Detail:
Type:  Journal Article     Date:  2010-11-06
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  27     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  793-802     Citation Subset:  IM    
Department of Pediatrics, Chinese PLA General Hospital, 100853, Beijing, China,
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