| Total synthesis of (-)-orthodiffenes A and C. | |
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MedLine Citation:
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PMID: 23051061 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The efficient and concise synthesis of (-)-orthodiffenes A and C has been accomplished for the first time in 8 steps from readily available chiral synthons, D-mannose and D-ethyl lactate. Our work confirmed the complete structure of orthodiffenes A and C, including their absolute stereochemistry. The key steps of our total synthesis involved cis-fused tetrahydrofuran cyclization, one-pot deprotection-lactonization, and intramolecular benzoyl migration according to a biosynthetic hypothesis of orthodiffenes. |
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Authors:
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Jun Liu; Yi Liu; Xing Zhang; Chaoli Zhang; Yangguang Gao; Linlin Wang; Yuguo Du |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: - ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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