Document Detail

Total synthesis of (-)-Isatisine A.
MedLine Citation:
PMID:  23153399     Owner:  NLM     Status:  Publisher    
A modular total synthesis of (-)-isatisine A is described in which four consecutive metal-mediated transformations have been employed at the final stage. These include [Pd]-catalyzed Sonogashira coupling, [Pd]-catalyzed nitroalkyne cycloisomerization leading to isatogens, addition of indoles to isatogens using InCl3 and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide bond. In addition to these, the removal of the protecting groups has also been carried out in a selective fashion employing either catalytic or stoichiometric metal/metal-based reagents respectively.
Pitambar Patel; Chepuri V Ramana
Related Documents :
22413339 - Photoelectric properties of tio2-zro2 thin films prepared by sol-gel method.
22976449 - Rhodium-catalyzed cross-aldol reaction: in situ aldehyde-enolate formation from allylox...
22905319 - Self-activated ultrahigh chemosensitivity of oxide thin film nanostructures for transpa...
24195579 - Synthesis of highly-substituted enantiomerically pure allylboronic esters and investiga...
22421789 - Synthesis of tetrasubstituted alkenes via metathesis.
23311959 - Cobalt-catalyzed acceptorless alcohol dehydrogenation: synthesis of imines from alcohol...
11281779 - Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin b.
12743769 - Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-...
12895049 - Kinetic study of the phenolysis of o-methyl and o-phenyl o-2,4-dinitrophenyl thiocarbon...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Laparoscopic umbilical hernia repair is the preferred approach in obese patients.
Next Document:  Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation.