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Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.
MedLine Citation:
PMID:  23033172     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The first total synthesis of (29S,37S)-malevamide E (), a potent ion channel inhibitor, has been achieved in a convergent fashion involving Julia-Kocienski olefination, Urpi acetal aldol and Shiina macrolactonization reactions as the key steps. The strategy developed herein is amenable for the synthesis of the other possible isomers in search for the correct stereoisomer of the naturally occurring molecule.
Authors:
Praveen Kumar Gajula; Shrikant Sharma; Ravi Sankar Ampapathi; Tushar Kanti Chakraborty
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
CSIR-Central Drug Research Institute, Lucknow-226 001, India. charkraborty@cdri.res.in.
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