| Total serum cholesterol and recovery from disability among hospitalized older adults. | |
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MedLine Citation:
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PMID: 16870637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The association between total serum cholesterol and health outcomes among older adults is controversial. The objective of the present study was to determine within a cohort of acutely hospitalized disabled elderly patients whether total cholesterol predicts recovery from disability in basic activities of daily living (ADL). METHODS: Patients (3150) 65 years old or older admitted to 81 acute care units in Italy and presenting with ADL disability at hospital admission were included in this study. ADL disability was defined as need of assistance or total dependence in one or more ADLs (eating, dressing, personal hygiene, transferring, and toilet use). Recovery was defined as no disability at hospital discharge in any of the five ADLs considered. RESULTS: Mean age of study participants was 80.5 +/- 7.2 years, and 1305 (41.1%) were men. The rate of recovery from ADL disability was 14.5% for participants with total cholesterol < 200 mg/dL (n = 306/2108), 20.2% for those with total cholesterol between 200 and 239 mg/dL (n = 144/713), and 23.1% for those with total cholesterol > or = 240 mg/dL (n = 76/329). After adjustment for potential confounders, relative to that of patients with cholesterol < 200 mg/dL, risk ratios for recovery were 1.31 for participants with cholesterol between 200 and 239 mg/dL (95% confidence interval [CI], 1.07-1.62) and 1.36 (95% CI, 1.04-1.79) for those with cholesterol > or = 240 mg/dL. After exclusion of 769 patients with total cholesterol < 145 mg/dL, the risk ratios (compared with those for participants with cholesterol < 200 mg/dL) for recovery were 1.33 (95% CI, 1.07-1.66) for participants with cholesterol between 200 and 239 mg/dL and 1.41 (95% CI, 1.06-1.88) for patients with cholesterol > or = 240 mg/dL. CONCLUSIONS: Among hospitalized disabled older adults, elevated levels of cholesterol are associated with increased rate of recovery from ADL disability. |
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Authors:
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Graziano Onder; Stefano Volpato; Rosa Liperoti; Carola D'Arco; Cinzia Maraldi; Renato Fellin; Roberto Bernabei; Francesco Landi; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 61 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-27 Completed Date: 2006-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 736-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy. graziano_onder@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Aged Aged, 80 and over Chi-Square Distribution Cholesterol / blood* Disability Evaluation Disabled Persons Female Geriatric Assessment Hospitalization* Humans Italy Male Poisson Distribution Predictive Value of Tests Recovery of Function* |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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