| Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults. | |
| | |
MedLine Citation:
|
PMID: 19076539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Effects of air pollution exposure on IgE-mediated response in asthmatics are poorly investigated. The aim was to examine the relationship between air pollution concentrations and total IgE levels in adult asthmatics. METHODS: The present study relates to the 369 asthmatic adults from the French Epidemiological study on Genetics and Environment of Asthma (EGEA), with availability of data on both total serum IgE measurements and air pollution concentrations. Geo-statistical models were performed on 4 x 4 km grids to assess individual outdoor air pollution exposure. Annual outdoor concentrations of ozone (O(3)), nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), and particulate matter smaller than 10 microm size (PM(10)), and concentrations of summer ozone were assigned to subject's home address. RESULTS: The geometric mean of total IgE was 161 IU/ml and the average of O(3) exposure was 44.9 +/- 9.5 microg/m(3). Ozone concentrations were positively related to total IgE levels and an increase of 10 microg/m(3) of O(3) resulted in an increase of 20.4% (95% CI = 3.0-40.7) in total IgE levels. Adjustment for age, gender, smoking habits and previous life in the countryside did not change the results, and an increase of 19.1% (2.4-38.6) in total IgE was observed with O(3). Negative associations observed between NO(2) and total IgE levels disappeared after including O(3) in the models. Neither SO(2) nor PM(10) were correlated with total IgE levels. CONCLUSIONS: Results suggest that O(3) or related ambient pollutants may up-regulate total IgE levels among asthmatic adults. |
| | |
Authors:
|
E Rage; B Jacquemin; R Nadif; M-P Oryszczyn; V Siroux; I Aguilera; F Kauffmann; N Künzli; |
Related Documents
:
|
22868139 - Curcuma longa and curcuma mangga leaves exhibit functional food property. 14500159 - Sevoflurane in exhaled air of operating room personnel. 22538129 - Implications of the new food and drug administration draft guidance on human factors en... 16650739 - Design and in vitro performance testing of multiple air classifier technology in a new ... 11529139 - Quantification of re-evaporated mass from loaded fibre-mist eliminators. 7153139 - Deposition and clearance of inhaled aerosol in the respiratory tract of chickens. 1208189 - Pesticide residues in total diet samples (viii). 3973309 - Evaluation of immediate adverse reactions to foods in adult patients. i. correlation of... 12379309 - Cholesterol crystallite nucleation in supersaturated model biles from a thermodynamic s... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-28 |
Journal Detail:
|
Title: Allergy Volume: 64 ISSN: 1398-9995 ISO Abbreviation: Allergy Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-09 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804028 Medline TA: Allergy Country: Denmark |
Other Details:
|
Languages: eng Pagination: 40-6 Citation Subset: IM |
Affiliation:
|
Inserm, U780, Epidemiology and Biostatistics, Villejuif, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Air Pollution / adverse effects Asthma / epidemiology, etiology, immunology* Family Health Female Humans Immunoglobulin E / blood* Male Middle Aged Oxidants, Photochemical / adverse effects Ozone / adverse effects* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Oxidants, Photochemical; 10028-15-6/Ozone; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting the MHC class II pathway of antigen presentation enhances immunogenicity and safety of all...
Next Document: Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency.