Document Detail

Total and percent atropisomers of gossypol and gossypol-6-methyl ether in seeds from pima cottons and accessions of Gossypium barbadense L.
MedLine Citation:
PMID:  19113939     Owner:  NLM     Status:  MEDLINE    
Gossypol occurs naturally in the seed, foliage, and roots of the cotton plant ( Gossypium ) as atropisomers due to restricted rotation around the binaphthyl bond. The atropisomers differ in their biological activities. (-)-(R)-Gossypol is more toxic and exhibits significantly greater anticancer activity than the (+)-(S)-atropisomer. Most commercial Upland ( Gossypium hirsutum ) cottonseeds have an (R)- to (S)-gossypol ratio of approximately 2:3, but some Pima ( Gossypium barbadense ) seeds have an excess of (R)-gossypol. There is no known source of cottonseed with an (R)- to (S)-gossypol ratio of greater than approximately 70:30. Cottonseed with a high percentage of (R)-gossypol would be of value to the pharmaceutical industry. It was theorized that G. barbadense cotton might be a source of this desirable high (R)-gossypol seed trait. There are 671 different accessions of G. barbadense in the U.S. Cotton Germplasm Collection, few of which had been characterized with respect to their (R)- to (S)-gossypol ratio. This work completed that analysis and found considerable variation in the atropisomer ratio. Approximately half of the accessions have an excess of (R)-gossypol, and 52 accessions have essentially a 1:1 ratio. The highest percentage of (R)-gossypol was found in accessions GB26 (68.2%) and GB283 (67.3%). Surprisingly, five accessions had 5% or less of (R)-gossypol: GB516 (5.0%), GB761 (4.5%), GB577 (4.3%), GB719 (3.7%), and GB476 (2.3%). These accessions may be useful in a breeding program to reduce (R)-gossypol in Pima seed, which is a concern to the dairy industry because of the toxicity and male antifertility activity of this atropisomer. Also, GB710 was devoid of gossypol.
Robert D Stipanovic; Lorraine S Puckhaber; Jinggao Liu; Alois A Bell
Related Documents :
1455609 - Sudden death in ten psittacine birds associated with the operation of a self-cleaning o...
17336439 - Arsenic in seaweed--forms, concentration and dietary exposure.
17092619 - Seafood arsenic: implications for human risk assessment.
17904219 - Multiple stressor effects of herbicide, ph, and food on wetland zooplankton and a larva...
22566109 - Tissuespeciesdose, administrationduration of treatmentplasma/serum or tissue concentrat...
22430569 - Influence of saponins and tannins on intake and nutrient digestion of alkaloid-containi...
8634549 - Emergence of rapid methods for identifying microbial pathogens in foods.
11409299 - Bioavailability of iodine from normal diets rich in dairy products--results of balance ...
20843399 - Impact of foods with health logo on saturated fat, sodium and sugar intake of young dut...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  57     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-71     Citation Subset:  IM    
Southern Plains Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, College Station, Texas 77845, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Crosses, Genetic
Gossypium / chemistry*,  genetics
Gossypol / chemistry*
Seeds / chemistry*,  genetics
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of the reactivity of bis(mu-oxo)Cu(II)Cu(III) and Cu(III)Cu(III) species to methane.
Next Document:  Design of silica networks for development of highly permeable hydrogen separation membranes with hyd...