Document Detail

Total parenteral nutrition-related liver disease.
MedLine Citation:
PMID:  9473812     Owner:  NLM     Status:  MEDLINE    
Administration of parenteral nutrition to the small infant has decreased morbidity but is associated with the development of cholestasis and liver dysfunction in a high proportion of infants. In this review, contributing factors of the etiopathogenesis of parenteral nutrition-associated liver disease will be outlined, forming the basis for a unifying theory of its pathogenesis. It is proposed that oxidant stress and stimulation of hepatic Kupffer cells by bacterial cell wall products absorbed from the injured intestine are major factors leading to cholestasis and liver injury during prolonged parenteral nutrition. Improved outcome in patients has been related to the early introduction of feedings. New proposed therapeutic modalities have included antibiotics and probiotics to prevent bacterial overgrowth of the small intestine, enterally-administered ursodeoxycholic acid and intravenous cholecystokinin. Improved understanding of the fundamental mechanisms producing liver injury and fibrosis during parenteral nutrition will lead to new preventative and treatment measures in the future.
R J Sokol
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui     Volume:  38     ISSN:  0001-6578     ISO Abbreviation:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-03-05     Completed Date:  1998-03-05     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  16210470R     Medline TA:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  418-28     Citation Subset:  IM    
Pediatric Liver Center, University of Colorado School of Medicine, Denver 80218-1088, USA.
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MeSH Terms
Cholestasis / diagnosis,  etiology,  physiopathology,  therapy
Liver Diseases / diagnosis,  etiology*,  physiopathology,  therapy
Parenteral Nutrition, Total / adverse effects*

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