Document Detail

Total parenteral nutrition in children and adolescents treated with high-dose chemotherapy followed by autologous haematopoietic transplants.
MedLine Citation:
PMID:  19860986     Owner:  NLM     Status:  MEDLINE    
Total parenteral nutrition (TPN) is still of great importance for haematopoietic stem cell transplantation (HSCT) patients because one of the major adverse effects of the high-dose therapy followed by HSCT is an inadequate oral nutrition intake. The aim of the study was analysis of TPN of young patients in the HSCT period. Twenty-two patients 1.8-20.8 year-old, median 5.4, treated with high-dose therapy and autologous HSCT because of malignancy were included into the study. Grafts contained 1.35-7.9 x 106, median 3.75 x 106 CD34+ cells/kg. Engraftment occurred as follows: granulocytes >0.5 x 109/l on +11 d (8-25); platelets >20 x 109/l on +23 d (12-67). Patients were given isoenergetic, isonitrogenous TPN until they consumed less than 50 % of their required diet orally. Proteins intake was 0.8-2.0 g/kg per d, fats intake 1.0-3.0 g/kg per d. Total non-proteins energies-nitrogen grams index was 140:1-200:1. Supplementation of electrolytes, microelements, trace elements and vitamins was dependent on individual patient requirement. TPN duration did not correlate with CD34+ cells number but correlated with platelets reconstitution. The assessment of nutritional condition demonstrated no differences in anthropometric parameters, but increase of serum albumin levels after TPN. Requirement for P3 - was above the normal ranges and correlated positively with platelets reconstitution. Requirement for P3 - and K+ was higher in patients with mucositis than in other patients. Any complications due to TPN were observed. Adequately composed isoenergetic and isonitrogenous TPN with replacement of electrolytes according to their requirement in the early post-transplantation period allows not only improvement in nutritional status of patients but also could contribute to reconstitution of haematopoiesis.
Anna Wedrychowicz; Miko?aj Spodaryk; Aleksandra Krasowska-Kwiecie?; Jolanta Go?dzik
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Publication Detail:
Type:  Journal Article     Date:  2009-10-28
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  899-906     Citation Subset:  IM    
Transplantation Centre, University Children's Hospital, Cracow, Poland.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Calcium / administration & dosage
Child, Preschool
Endodermal Sinus Tumor / therapy
Hematopoietic Stem Cell Transplantation*
Hodgkin Disease / therapy
Magnesium / administration & dosage
Neoplasms / therapy*
Neuroblastoma / therapy
Nutritional Status
Parenteral Nutrition, Total*
Potassium / administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
Sarcoma, Ewing's / therapy
Transplantation, Autologous
Treatment Outcome
Young Adult
Reg. No./Substance:
7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-70-2/Calcium

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