Document Detail

Total occlusion of the infarct-related coronary artery correlates with brachial artery flow-mediated dilation in patients with ST-elevation myocardial infarction.
MedLine Citation:
PMID:  19199114     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Occlusion of the coronary artery is the main cause of ST-elevation myocardial infarction (STEMI). In some patients, it is followed by early spontaneous thrombolysis. In this study, we tried to determine whether spontaneous thrombolysis in the infarct-related artery (IRA) correlates with the state of the endothelium, which we assessed using the brachial artery flow-mediated dilation (FMD) test. METHODS: 52 patients with STEMI were included in the study. Based on the results of coronary angiography performed during the first three days of STEMI, the patients were divided into two groups: Group I (n=33), consisting of patients with remaining total occlusion of the IRA, and Group II (n=19), consisting of patients with spontaneous thrombolysis. We assessed the endothelial function, using the brachial artery FMD test. RESULTS: In Group I, during the first three days of STEMI, brachial artery FMD results were significantly lower than those in Group II: 5.41+/- (3.23-7.41)% versus 10.81+/-(8.00-14.89)%, respectively; P=0.000036. After 7-14 days, this difference disappeared because of significant elevation of the FMD levels in the first group. Group I was characterized by higher levels of high sensitive C-reactive protein (CRP), cholesterol, and cholesterol-LDL and lower usage of angiotensin-converting enzyme (ACE) inhibitors before STEMI. CONCLUSION: The data presented above reveal that spontaneous coronary thrombolysis in patients with acute STEMI is associated with a preserved endothelium-dependent vasodilator response in the brachial artery. It can depend on the levels of hs-CRP, of fasting glucose, and of ACE-inhibitors from previous treatment.
Elena Vasilieva; Irina Urazovskaya; Dmitriy Skrypnik; Alexander Shpektor
Related Documents :
19546284 - Early administration of thrombolysis can prevent myocardial necrosis: time is myocardium.
15542294 - A randomized trial of coronary stenting versus balloon angioplasty as a rescue interven...
8409074 - Identification of a secondary peak in myocardial infarction onset 11 to 12 hours after ...
17587714 - Improvement of postprandial hyperglycemia has a positive impact on epicardial flow of e...
11197784 - Intermittent nitrate therapy for prior myocardial infaraction does not induce rebound a...
13820324 - Heparin in acute myocardial infarction: observations indicating the potential advantage...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  11     ISSN:  1748-295X     ISO Abbreviation:  Acute Card Care     Publication Date:  2009  
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Cardiology, Moscow State University of Medicine and Dentistry, Moscow, Russia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Brachial Artery / physiopathology*
Coronary Circulation* / drug effects
Coronary Occlusion / drug therapy,  physiopathology*
Electrocardiogram Pattern
Endothelium, Vascular / drug effects,  physiopathology*
Middle Aged
Myocardial Infarction / physiopathology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Application of TEM and XPS in the interpretation of the kinetics of deuterium evolution from ultrath...
Next Document:  Role of particle coating in controlling skin damage photoinduced by titania nanoparticles.