| Total occlusion of the infarct-related coronary artery correlates with brachial artery flow-mediated dilation in patients with ST-elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 19199114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Occlusion of the coronary artery is the main cause of ST-elevation myocardial infarction (STEMI). In some patients, it is followed by early spontaneous thrombolysis. In this study, we tried to determine whether spontaneous thrombolysis in the infarct-related artery (IRA) correlates with the state of the endothelium, which we assessed using the brachial artery flow-mediated dilation (FMD) test. METHODS: 52 patients with STEMI were included in the study. Based on the results of coronary angiography performed during the first three days of STEMI, the patients were divided into two groups: Group I (n=33), consisting of patients with remaining total occlusion of the IRA, and Group II (n=19), consisting of patients with spontaneous thrombolysis. We assessed the endothelial function, using the brachial artery FMD test. RESULTS: In Group I, during the first three days of STEMI, brachial artery FMD results were significantly lower than those in Group II: 5.41+/- (3.23-7.41)% versus 10.81+/-(8.00-14.89)%, respectively; P=0.000036. After 7-14 days, this difference disappeared because of significant elevation of the FMD levels in the first group. Group I was characterized by higher levels of high sensitive C-reactive protein (CRP), cholesterol, and cholesterol-LDL and lower usage of angiotensin-converting enzyme (ACE) inhibitors before STEMI. CONCLUSION: The data presented above reveal that spontaneous coronary thrombolysis in patients with acute STEMI is associated with a preserved endothelium-dependent vasodilator response in the brachial artery. It can depend on the levels of hs-CRP, of fasting glucose, and of ACE-inhibitors from previous treatment. |
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Authors:
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Elena Vasilieva; Irina Urazovskaya; Dmitriy Skrypnik; Alexander Shpektor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acute cardiac care Volume: 11 ISSN: 1748-295X ISO Abbreviation: Acute Card Care Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101276603 Medline TA: Acute Card Care Country: England |
Other Details:
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Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Moscow State University of Medicine and Dentistry, Moscow, Russia. helena_vasilieva@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use Brachial Artery / physiopathology* Coronary Circulation* / drug effects Coronary Occlusion / drug therapy, physiopathology* Electrocardiogram Pattern Endothelium, Vascular / drug effects, physiopathology* Female Fibrinolysis Humans Male Middle Aged Myocardial Infarction / physiopathology* Prognosis Vasodilation* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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