| Total nitrogen oxide following exercise testing reflects endothelial function and discriminates health status. | |
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MedLine Citation:
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PMID: 16895794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) bioavailability is important in vascular health, but unsuitable as a clinical measure due to biological oxidation. Total nitrogen oxides (NO(x)) are stable but background nitrate levels make it difficult to detect disease-based variation. We investigated the clinical discriminatory value of NO(x) as it relates to exercise capability (VO(2peak)) and brachial artery reactivity (BAR, an NO-dependent measure of endothelial health), in healthy (H), increased risk (RF), and known cardiovascular disease (CVD) subjects. BAR was measured using forearm occlusion/hyperemia stimulus. Subjects performed a maximal graded exercise test (GXT). Blood at rest, exercise termination, and 10 min into recovery was mixed equally with 0.1 M NaOH at 4 degrees C, filtered, and stored at -70 degrees C. NO(x) was measured by chemiluminescence. Seven of the RF group then exercise-trained for 6 months prior to retesting. The H group (n = 12) was younger, had higher VO(2peak), HDL levels, and baseline NO(x) values than the RF (n = 15) and CVD (n = 10) groups. NO(x) increased from baseline to recovery in the H group only (75.85 +/- 19.04 microM vs 97.76 +/- 31.93 microM; P <or= 0.01). BAR was greater in the H versus CVD group (7.24 +/- 3.78% vs 2.59 +/- 3.53%; P <or= 0.01). The relation between VO(2peak) and NO(x) recovery was significant across groups (r = 0.71, P <or= 0.01). Following training the RF subjects (n = 7) increased VO(2peak) (29.98 +/- 6.74 to 33.08 +/- 5.57 ml kg(-1) min(-1); P <or= 0.05), BAR (3.19 +/- 3.96 to 6.86 +/- 4.81%; P <or= 0.05), and recovery NO(x) (18.29 +/- 6.46 to 66.48 + 21.11 microM; P <or= 0.01). These findings suggest that plasma NO(x) following GXT discriminate cardiovascular disease status, are related to regional endothelial function, and respond favorably to exercise training. |
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Authors:
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Jason D Allen; Frederick R Cobb; William E Kraus; Andrew J Gow |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-05-23 |
Journal Detail:
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Title: Free radical biology & medicine Volume: 41 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-09 Completed Date: 2007-02-12 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 740-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Duke University Medical Center, Center for Living Campus, DUMC 3022, Durham, NC 27710, USA. j.d.allen@duke.edu <j.d.allen@duke.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Diseases / metabolism* Endothelium, Vascular / metabolism* Exercise Female Health Status Humans Male Nitrogen Oxides / chemistry*, metabolism* Oxygen / metabolism Physical Endurance Risk Factors Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 57354/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Oxides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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