| Total lymphoid irradiation for treatment of intractable cardiac allograft rejection. | |
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MedLine Citation:
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PMID: 2031918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of postoperative total lymphoid irradiation to reverse otherwise intractable cardiac allograft rejection was examined in a group of 10 patients in whom conventional rejection therapy (including pulsed steroids and monoclonal or polyclonal anti-T-cell antibody therapy) had failed to provide sustained freedom from rejection. Follow-up periods range from 73 to 1119 days since the start of total lymphoid irradiation. No patient died or sustained serious morbidity because of the irradiation. Three patients have had no further rejection (follow-up periods, 105 to 365 days). Two patients died--one in cardiogenic shock during the course of total lymphoid irradiation, the other with recurrent rejection caused by noncompliance with his medical regimen. Total lymphoid irradiation appears to be a safe and a moderately effective immunosuppressive modality for "salvage" therapy of cardiac allograft rejection unresponsive to conventional therapy. |
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Authors:
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S A Hunt; S Strober; R T Hoppe; E B Stinson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 10 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 1991 Mar-Apr |
Date Detail:
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Created Date: 1991-06-27 Completed Date: 1991-06-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 211-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Stanford University Medical Center, CA 94305. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Female Follow-Up Studies Graft Rejection / immunology, radiation effects* Heart Transplantation / immunology* Humans Immunosuppression / methods* Lymphatic Irradiation* Male Middle Aged Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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