Document Detail


Total lymphoid irradiation for treatment of intractable cardiac allograft rejection.
MedLine Citation:
PMID:  2031918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of postoperative total lymphoid irradiation to reverse otherwise intractable cardiac allograft rejection was examined in a group of 10 patients in whom conventional rejection therapy (including pulsed steroids and monoclonal or polyclonal anti-T-cell antibody therapy) had failed to provide sustained freedom from rejection. Follow-up periods range from 73 to 1119 days since the start of total lymphoid irradiation. No patient died or sustained serious morbidity because of the irradiation. Three patients have had no further rejection (follow-up periods, 105 to 365 days). Two patients died--one in cardiogenic shock during the course of total lymphoid irradiation, the other with recurrent rejection caused by noncompliance with his medical regimen. Total lymphoid irradiation appears to be a safe and a moderately effective immunosuppressive modality for "salvage" therapy of cardiac allograft rejection unresponsive to conventional therapy.
Authors:
S A Hunt; S Strober; R T Hoppe; E B Stinson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  10     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-06-27     Completed Date:  1991-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Stanford University Medical Center, CA 94305.
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Female
Follow-Up Studies
Graft Rejection / immunology,  radiation effects*
Heart Transplantation / immunology*
Humans
Immunosuppression / methods*
Lymphatic Irradiation*
Male
Middle Aged
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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