Document Detail

Total lymphoid irradiation in refractory systemic lupus erythematosus.
MedLine Citation:
PMID:  3717808     Owner:  NLM     Status:  MEDLINE    
In two patients with systemic lupus erythematosus, conventional therapy was considered to have failed because of persistent disease activity and unacceptable side effects. Both were treated with total lymphoid irradiation without clinical benefit, despite adequate immunosuppression as documented by markedly reduced numbers of circulating T lymphocytes and T-lymphocyte-dependent proliferative responses in vitro. The first patient developed herpes zoster, gram-negative septicemia, neurologic symptoms, and deterioration of lupus nephritis. The second patient developed massive bronchopneumonia, necrotic cutaneous lesions, and progressive nephritis and died 2 weeks after completion of radiotherapy. These observations, although limited to two patients, indicate that total lymphoid irradiation in patients with severe systemic lupus erythematosus should be regarded as strictly experimental.
E Ben-Chetrit; D J Gross; A Braverman; Z Weshler; Z Fuks; S Slavin; M Eliakim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  105     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-07-22     Completed Date:  1986-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-60     Citation Subset:  AIM; IM    
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MeSH Terms
Azathioprine / therapeutic use
Drug Resistance
Immunosuppression / methods*
Lupus Erythematosus, Systemic / drug therapy,  immunology,  radiotherapy*
Lymphocyte Activation / radiation effects
Lymphoid Tissue / radiation effects*
Prednisone / therapeutic use
Radiation Injuries
Radiotherapy Dosage
Reg. No./Substance:
446-86-6/Azathioprine; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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