Document Detail


Total liquid ventilation provides ultra-fast cardioprotective cooling.
MedLine Citation:
PMID:  17276185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We tested whether total liquid ventilation (TLV) can be used to rapidly cool and protect the infarcting heart. BACKGROUND: Decreasing myocardial temperature during ischemia is a powerful cardioprotective strategy, but clinical application has been impaired by lack of practical methodology to quickly cool the heart. METHODS: We performed 30-min coronary artery occlusion/3-h reperfusion in rabbits. Upon occlusion, rabbits underwent either oxygen (Gas), normothermic liquid (Liquid Warm), or cold liquid (Liquid Cool) ventilation. RESULTS: Left atrial chamber temperature decreased to 32.4 degrees +/- 0.2 degrees C within 5 min of onset of cold TLV. Blood gases were within acceptable limits during TLV. In the Liquid Warm group, perfluorocarbon inhalation did not alter infarct size compared with Gas (37.7 +/- 1.3% and 42.5 +/- 4.9% of risk zone, respectively). However, infarction was significantly reduced in the Liquid Cool group (4.0 +/- 0.5%). Cooling only during the initial 30 min of reperfusion did not reduce infarction. CONCLUSIONS: Total liquid ventilation can elicit rapid cardioprotective cooling during ischemia.
Authors:
Renaud Tissier; Kazutoshi Hamanaka; Atsushi Kuno; James C Parker; Michael V Cohen; James M Downey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-22
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  49     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Physiology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Disease Models, Animal
Fluorocarbons / administration & dosage*
Heart Rate / physiology
Hypothermia, Induced / methods*
Liquid Ventilation / methods*
Myocardial Infarction / pathology*,  physiopathology,  prevention & control*
Rabbits
Time Factors
Grant Support
ID/Acronym/Agency:
HL-20468/HL/NHLBI NIH HHS; HL-50688/HL/NHLBI NIH HHS; HL-57040/HL/NHLBI NIH HHS; HL-66299/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fluorocarbons
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2007 Feb 6;49(5):606-7   [PMID:  17276186 ]

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