| Total liquid ventilation provides ultra-fast cardioprotective cooling. | |
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MedLine Citation:
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PMID: 17276185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We tested whether total liquid ventilation (TLV) can be used to rapidly cool and protect the infarcting heart. BACKGROUND: Decreasing myocardial temperature during ischemia is a powerful cardioprotective strategy, but clinical application has been impaired by lack of practical methodology to quickly cool the heart. METHODS: We performed 30-min coronary artery occlusion/3-h reperfusion in rabbits. Upon occlusion, rabbits underwent either oxygen (Gas), normothermic liquid (Liquid Warm), or cold liquid (Liquid Cool) ventilation. RESULTS: Left atrial chamber temperature decreased to 32.4 degrees +/- 0.2 degrees C within 5 min of onset of cold TLV. Blood gases were within acceptable limits during TLV. In the Liquid Warm group, perfluorocarbon inhalation did not alter infarct size compared with Gas (37.7 +/- 1.3% and 42.5 +/- 4.9% of risk zone, respectively). However, infarction was significantly reduced in the Liquid Cool group (4.0 +/- 0.5%). Cooling only during the initial 30 min of reperfusion did not reduce infarction. CONCLUSIONS: Total liquid ventilation can elicit rapid cardioprotective cooling during ischemia. |
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Authors:
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Renaud Tissier; Kazutoshi Hamanaka; Atsushi Kuno; James C Parker; Michael V Cohen; James M Downey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-01-22 |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 49 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-04-03 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 601-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Disease Models, Animal Fluorocarbons / administration & dosage* Heart Rate / physiology Hypothermia, Induced / methods* Liquid Ventilation / methods* Myocardial Infarction / pathology*, physiopathology, prevention & control* Rabbits Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-20468/HL/NHLBI NIH HHS; HL-50688/HL/NHLBI NIH HHS; HL-57040/HL/NHLBI NIH HHS; HL-66299/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fluorocarbons |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2007 Feb 6;49(5):606-7
[PMID:
17276186
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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