| Total knee arthroplasty and Crigler-Najjar syndrome: a case report. | |
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MedLine Citation:
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PMID: 19751978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Crigler-Najjar (CN) syndrome is a rare genetic disease characterized by hyperbilirubinemia due to a deficiency in the hepatic enzyme UDP-glucuronosyl-transferase. We describe the first case of total knee arthroplasty in a patient with CN syndrome (type II). This procedure was complicated by kernicterus 1 week after hospital discharge. He also developed Klebsiella bacteremia and sepsis, requiring a brief ICU stay. He was discharged in good condition 2 months later. It is evident that physicians involved in the care of patients with CN syndrome in the peri-operative period need to have a high index of suspicion for the development of severe hyperbilirubinemia and kernicterus in order to appropriately manage and, possibly, prevent this complication. A literature review and intra-operative observations provide insight into the possible relationship between hyperbilirubinemia and osteoarthritis as well as the peri-operative considerations to be made for this group of patients. |
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Authors:
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David Walmsley; Khalid Alzaharani; William J Coke; Rajiv Gandhi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-13 |
Journal Detail:
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Title: The Knee Volume: 17 ISSN: 1873-5800 ISO Abbreviation: Knee Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430798 Medline TA: Knee Country: Netherlands |
Other Details:
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Languages: eng Pagination: 252-4 Citation Subset: IM |
Affiliation:
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Division of Orthopedic Surgery, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthroplasty, Replacement, Knee
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adverse effects* Crigler-Najjar Syndrome / complications* Humans Kernicterus / etiology*, therapy Klebsiella Infections / etiology* Male Middle Aged Osteoarthritis / etiology, surgery* Osteophyte / etiology, surgery Plasma Exchange Recovery of Function Shock, Septic / complications, etiology*, microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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