Document Detail

Total and ionized serum magnesium in critically ill patients.
MedLine Citation:
PMID:  15605229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the alterations in total serum magnesium (tsMg) and ionized serum magnesium (Mg(2+)) and their association with prognosis in critically ill patients. DESIGN AND SETTING: Prospective, cohort study in the intensive care unit (ICU) of a university teaching hospital. PATIENTS: Adult patients admitted to the ICU without previous factors influencing magnesium homeostasis were included during a 6-month period. MEASUREMENTS AND RESULTS: One hundred forty four patients were included. Mean age was 60.6+/-15.4 years; mean APACHE II score was 12.6+/-6.9. Blood samples were collected in the first 24 h after ICU admission and again on the second, third, and last days of stay in the ICU. At ICU admission 52.5% had total hypomagnesemia and 13.5% total hypermagnesemia; with respect to the Mg(2+) 9.7% showed ionized hypomagnesemia and 23.6% ionized hypermagnesemia. Patients who developed ionized hypermagnesemia had higher mortality than patients without ionized hypermagnesemia development (P=0.04). A moderate correlation between tsMg and Mg(2+) concentrations was found; however, a number of patients with total hypomagnesemia (69-85% during the study) had ionized normomagnesemia. The measure of agreement between tsMg and Mg(2+) levels was poor. CONCLUSIONS: Magnesium alterations are frequently found in critically ill patients. The usually determined tsMg levels are not a reflection of Mg(2+) levels. Development of ionized hypermagnesemia is associated with prognosis.
Maria Paz Escuela; Manuel Guerra; José M Añón; Vicente Martínez-Vizcaíno; María Dolores Zapatero; Angel García-Jalón; Sebastian Celaya
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Publication Detail:
Type:  Journal Article     Date:  2004-12-17
Journal Detail:
Title:  Intensive care medicine     Volume:  31     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-14     Completed Date:  2005-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Intensive Care Unit, Hospital Clínico Universitario, Zaragoza, Spain.
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MeSH Terms
Intensive Care Units
Magnesium / blood*
Magnesium Deficiency / mortality*
Middle Aged
Prospective Studies
Reg. No./Substance:

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