| Total gastrectomy causes a sustained, long-term elevation of somatostatin in plasma, independent of the mode of reconstruction in pigs. | |
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MedLine Citation:
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PMID: 19368132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The long-term effects of gastrectomy and various reconstructions of the gastrointestinal tract on fasting plasma levels of gastrointestinal hormones known to contribute to the control of gastrointestinal motor function were evaluated in pigs. MATERIALS AND METHODS: Domestic pigs were randomly selected to sham surgery or total gastrectomy (TG) followed by reconstruction with oesophago-jejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition between the oesophagus and the duodenum (OJD), or an oesophagojejunostomy with a proximal jejunal pouch reservoir (J-pouch) on a Roux-en-Y loop. Blood was collected just before surgery and ten weeks later and peptide levels were analysed by radioimmunoassay. RESULTS: Somatostatin levels were sustained at a high level after TG, regardless of the mode of reconstruction, but were significantly lower in sham-operated animals. Levels of vasoactive intestinal peptide (VIP), neurotensin and motilin were unchanged. CONCLUSION: TG by itself leads to high levels of somatostatin long term, however, somatostatin, motilin, neurotensin and VIP are unaffected by the mode of reconstruction. |
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Authors:
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Ulrika Smedh; Lars Hansson; Rolf Ekman; Thomas Zilling |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 23 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-04-16 Completed Date: 2009-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 99-103 Citation Subset: IM |
Affiliation:
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Department of Surgery, Lund University Hospital, Lund, Sweden. ulrika.smedh@med.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Roux-en-Y* Animals Colonic Pouches* Disease Models, Animal Duodenum / surgery Esophagus / surgery Female Jejunum / surgery Male Nutritional Status Postgastrectomy Syndromes / blood*, pathology Somatostatin / blood* Swine |
| Chemical | |
Reg. No./Substance:
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51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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