| Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of lifea. | |
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MedLine Citation:
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PMID: 21854402 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Testosterone levels are commonly lowered in men with diabetes but it is unclear how these relate to symptoms of hypogonadism and quality of life. We sought to investigate the relationship between testosterone levels, symptoms of androgen deficiency, erectile function and quality of life in men with type 1 and type 2 diabetes. Design and subjects: Cross-sectional study of 115 men with type 2 diabetes, 93 men with type 1 diabetes and 121 healthy controls. Measurements: Total, bioavailable and free testosterone levels were measured or calculated by Vermuelen's formula. Quality of life and symptom scores were assessed by the Audit of Diabetes Dependent Quality of Life (ADDQoL), Androgen Deficiency in the Aging Male (ADAM) and International Index of Erectile Function (IIEF) questionnaires. Results: Forty-five and sixty-one percent of men with type 2 diabetes had low total and calculated free testosterone levels, respectively. Total testosterone levels were not lowered in men with type 1 diabetes but 32% had low calculated free testosterone. After adjustment for age and waist circumference, only calculated free testosterone in men with type 2 diabetes (-0.037 nmol/l, 95% CI -0.075 to -0.0003, p=0.048) remained lowered compared with controls. Calculated free testosterone correlated weakly with ADAM (r = -0.26, 95% CI -0.42 to -0.08, p=0.006), IIEF (r = 0.19, 95% CI 0.01 to 0.37, p=0.042) and ADDQoL (r = 0.21, 95% CI 0.03 to 0.38, p=0.022) scores in men with type 2, but not type 1 diabetes. Age exerted the predominant effect on erectile function in both groups, in a model incorporating age, testosterone level and complications. Conclusions: Testosterone levels are strongly affected by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and erectile function. Testosterone levels do not appear to be a major determinant of quality of life in patients with diabetes. |
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Authors:
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Mousumi Biswas; David Hampton; Robert G Newcombe; D Aled Rees |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Medicine Medical Biochemistry, Royal Gwent Hospital, Newport, UK Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, UK Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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