Document Detail

Total dose iron infusion: safety and efficacy in predialysis patients.
MedLine Citation:
PMID:  10718279     Owner:  NLM     Status:  MEDLINE    
Iron deficiency anemia is not uncommon in predialysis patients. Oral iron often cannot maintain adequate iron stores. Hence we evaluated the safety and efficacy of total dose infusion (TDI) of iron in these patients. Anemic predialysis patients were screened and those with Hb < 7.0 g/dL and serum ferritin < 200 ng/mL were selected. Patients with active bleeding and acute liver disease were excluded. All patients were on oral iron 100 mg/day. None of the patients were on erythropoeitin. 11 patients (6 males and 5 females), aged 45.9 +/- 15 yrs, were suitable. Hb was 5.9 +/- 1.0 g/dL and serum ferritin was 89.5 + 50 ng/mL. The preparation used was iron dextran. A test dose of 25 mg in 100 mL normal saline was administered over 1 hr to all patients. One patient had fever and chills during the test dose and was not given TDI. 10 patients received TDI. None of these patients had any problem during the infusion. The dose of iron administered was 900 + 316.2 mg. One patient who received 1600 mg had arthralgia-myalgia and another patient had thrombophlebitis following TDI. One month after TDI, Hb was 8.0 + 1.0 g/dL and serum ferritin was 362 ng/mL. We feel that TDI is a safe and effective method of correcting iron deficiency in predialysis patients.
D Bhowmik; G Modi; D Ray; S Gupta; S K Agarwal; S C Tiwari; S C Dash
Related Documents :
21749449 - The jak2v617f allele burden and stat3- and stat5 phosphorylation in myeloproliferative ...
7387309 - Primary hemochromatosis with hereditary spherocytosis.
21341549 - Is there a correlation between testosterone levels and the severity of the disease in m...
7104229 - Recurrent thrombocytopenia, erythroid hypoplasia and sideroblastic anaemia associated w...
17984039 - Clinical utility of beckman-coulter gen's reticulocyte analysis in the study of anemia ...
12087489 - Reactive macrophage activation syndrome: a simple screening strategy and its potential ...
16691299 - Clinical diagnosis of achalasia: how reliable is the barium x-ray?
6781399 - Measurement of optokinetic nystagmus for otoneurological diagnosis.
8417489 - Four-compartment fasciotomy and venous calf-pump function: long-term results.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  22     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-04-03     Completed Date:  2000-04-03     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Department of Nephrology, All India Institute of Medical Sciences, New Delhi.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Iron-Deficiency / drug therapy*,  etiology
Infusions, Intra-Arterial
Iron / administration & dosage*
Kidney Failure, Chronic / complications
Middle Aged
Pilot Projects
Renal Dialysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chloroquine inhibits arginine vasopressin production in isolated rat inner medullary segments induce...
Next Document:  Effects of prolonged infusion of the natriuretic peptides Escherichia coli enterotoxin and atrial na...