Document Detail


Total dose iron infusion: safety and efficacy in predialysis patients.
MedLine Citation:
PMID:  10718279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency anemia is not uncommon in predialysis patients. Oral iron often cannot maintain adequate iron stores. Hence we evaluated the safety and efficacy of total dose infusion (TDI) of iron in these patients. Anemic predialysis patients were screened and those with Hb < 7.0 g/dL and serum ferritin < 200 ng/mL were selected. Patients with active bleeding and acute liver disease were excluded. All patients were on oral iron 100 mg/day. None of the patients were on erythropoeitin. 11 patients (6 males and 5 females), aged 45.9 +/- 15 yrs, were suitable. Hb was 5.9 +/- 1.0 g/dL and serum ferritin was 89.5 + 50 ng/mL. The preparation used was iron dextran. A test dose of 25 mg in 100 mL normal saline was administered over 1 hr to all patients. One patient had fever and chills during the test dose and was not given TDI. 10 patients received TDI. None of these patients had any problem during the infusion. The dose of iron administered was 900 + 316.2 mg. One patient who received 1600 mg had arthralgia-myalgia and another patient had thrombophlebitis following TDI. One month after TDI, Hb was 8.0 + 1.0 g/dL and serum ferritin was 362 ng/mL. We feel that TDI is a safe and effective method of correcting iron deficiency in predialysis patients.
Authors:
D Bhowmik; G Modi; D Ray; S Gupta; S K Agarwal; S C Tiwari; S C Dash
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  22     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-04-03     Completed Date:  2000-04-03     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Affiliation:
Department of Nephrology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Iron-Deficiency / drug therapy*,  etiology
Female
Humans
Infusions, Intra-Arterial
Iron / administration & dosage*
Kidney Failure, Chronic / complications
Male
Middle Aged
Pilot Projects
Renal Dialysis
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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