| Total contact casting combined with human fibroblast-derived dermal tissue in 15 DFU patients. | |
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MedLine Citation:
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PMID: 22584742 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To investigate the use of a cryopreserved human fibroblast-derived dermal substitute (Dermagraft; DG) in combination with total contact casting (TCC) in patients with diabetic foot ulcers, compared with previously published rates of healing with TCC alone. Method: Fifteen consecutive diabetic foot ulcer patients were referred to a multi-speciality clinic to be managed with a combination of DG and TCC, after showing no progress toward healing following at least 4 weeks of standard, conservative therapy. Follow-up visits were scheduled every 7 days, for a period of 12 weeks, or until fully healed. At each visit, DG and TCC were applied by the investigating clinician, and ulcer size and depth were recorded. Photographs were taken once a month, or when healed. If indicated, debridement was done to remove fibrotic tissue, callus and slough. Results: The results demonstrated an average healing rate of 23.7 ± 16.3 days. The average number of DG applications was 2.1. There was no correlation observed between ulcer duration, or ulcer location (forefoot or mid-foot), and time to healing; however, a correlation was found between wound size and healing time. Conclusion: The findings may suggest combining advanced healing modalities, such as DG with TCC, can be done and that they may have a benefit of limiting the time spent in TCC, as well as a reduction in time to heal. The study size was small and further studies into combining modalities are warranted to validate these findings. Declaration of interest: Both authors have been paid consultants for Advanced Biohealing, the producers of Dermagraft (DG). There are no financial disclosures for Med Efficiency, Inc. (MedE-Kast Ultra; TCC), or any other conflicts of interest to declare. |
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Authors:
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H Kashefsky; W Marston |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of wound care Volume: 21 ISSN: 0969-0700 ISO Abbreviation: J Wound Care Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417080 Medline TA: J Wound Care Country: England |
Other Details:
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Languages: eng Pagination: 236-43 Citation Subset: N |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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