Document Detail

Total body water adjustment of mean alcohol intakes.
MedLine Citation:
PMID:  7780299     Owner:  NLM     Status:  MEDLINE    
Total body water volume (TBW) is one factor that determines the functional effect of a standard dose of alcohol. Because women and the elderly generally have lower TBW values than men and younger persons, respectively, less alcohol needs to be consumed by women and elders to achieve the same or higher blood alcohol levels compared to men and younger persons. An existing data set on elderly drinkers was analyzed with and without TBW adjustment of intakes using mean TBW estimates per decade for each gender. The estimates were obtained from a published report that pooled cross-sectional data to produce mean TBW values and TBW prediction equations applicable to Western populations. As the analyses confirm, the use of cutoff points of alcohol intake not adjusted for TBW results in drinking-level misclassification and findings biased towards younger males. This report supports the standard use of TBW-adjusted alcohol intakes in analyses of samples with both genders and/or a wide age range.
A L Mirand; J W Welte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of substance abuse     Volume:  6     ISSN:  0899-3289     ISO Abbreviation:  J Subst Abuse     Publication Date:  1994  
Date Detail:
Created Date:  1995-07-19     Completed Date:  1995-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9001404     Medline TA:  J Subst Abuse     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-25     Citation Subset:  IM    
Research Institute on Addictions, Buffalo, NY 14203, USA.
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MeSH Terms
Age Factors
Alcohol Drinking / adverse effects,  physiopathology*
Alcoholism / classification,  diagnosis,  physiopathology
Bias (Epidemiology)
Body Water / drug effects,  physiology*
Data Interpretation, Statistical
Ethanol / pharmacokinetics*
Middle Aged
Sex Factors
Water-Electrolyte Balance / drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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